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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

“垃圾從神經(jīng)元轉(zhuǎn)移到神經(jīng)膠質(zhì)細(xì)胞的標(biāo)準(zhǔn)流程的發(fā)現(xiàn)，zui有可能是理解大腦和神經(jīng)退行性或代謝紊亂的與年齡相關(guān)的衰退功能的關(guān)鍵，” Marsh-Armstrong說。“我們希望在生物醫(yī)學(xué)的其他領(lǐng)域上也有一樣重要的影響。”
研究人員仔細(xì)地觀察小鼠的視網(wǎng)膜神經(jīng)節(jié)細(xì)胞的軸突，這一種類型的神經(jīng)元從眼睛傳送視覺信息到大腦。結(jié)合*顯微鏡和Ellisman和Marsh-Armstrong實驗室開發(fā)的分子生物技術(shù)，他們發(fā)現(xiàn)，視網(wǎng)膜神經(jīng)節(jié)細(xì)胞的受損線粒體脫落在ONH中。這些線粒體由相鄰的星形膠質(zhì)細(xì)胞吸收和降解。
這項研究抗原抗體了傳統(tǒng)的觀點，即細(xì)胞內(nèi)部分離，降解和去除損壞的細(xì)胞器，這個過程通常被稱為自噬(希臘語為“自吃”)。當(dāng)這個過程涉及線粒體時，它被稱為線粒體自噬。Marsh-Armstrong， Ellisman和其同事們所描述的這個過程被命名為“transmitophagy”。
Ellisman說，這一發(fā)現(xiàn)可能提高對各種疾病的認(rèn)識，zui終也許為各種疾病的治療提供線索。“線粒體在軸突的健康中有著顯著的作用。優(yōu)*一步探索transmitophagy發(fā)生了什么，以及這一現(xiàn)象的缺陷是否導(dǎo)致神經(jīng)元功能障礙或疾病。”

"The discovery of the standard flow of trash from neurons to glial cells is most likely the key to understanding the age-related decline of brain and neurodegenerative or metabolic disorders," said Marsh-Armstrong. "We hope there will be equally important implications in other areas of biomedicine."
Researchers carefully examined the axons of retinal ganglion cells in mice, a type of neuron that sends visual information from the eye to the brain. Combined with advanced microscopy and molecular biology developed by Ellisman and Marsh-Armstrong Laboratories, they found that impaired mitochondrial detachment of retinal ganglion cells in ONH. These mitochondria are absorbed and degraded by adjacent astrocytes.
This study of antigen-antibody has the traditional view that the internal separation of cells, degradation and removal of damaged organelles, this process is often referred to as autophagy (Greek for "self-eating"). When this process involves mitochondria, it is called mitochondrial autophagy. The process described by Marsh-Armstrong, Ellisman and colleagues was named "transmitophagy."
Ellisman said the finding may raise awareness of various diseases and may eventually provide clues to the treatment of various diseases. "Mitochondria play a significant role in the health of axons, giving priority to further exploration of what happens to transmitophagy, and whether the flaws in this phenomenon lead to neuronal dysfunction or disease."